Development of Ryanodine Receptor (RyR) Inhibitors for Skeletal Muscle and Heart Diseases

Ryanodine receptors (RyR) are intracellular calcium (Ca2+) release channels on the sarcoplasmic reticulum of skeletal and cardiac muscles that play a central role in excitation-contraction coupling. Genetic mutations or posttranslational modifications RyR causes hyperactivation channel, leading to various muscle heart diseases. Currently, no specific treatments exist for most RyR-associated Recently, high-throughput screening (HTS) assays have been developed identify potential candidates treating RyR-related These successfully identified several compounds as novel inhibitors, which effective animal models. In this review, we will focus recent progress HTS discuss future perspectives these promising approaches.